6U0D
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
3 | A | N-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea | non-polymer | 512.5 | 1 | Chemie (POJ) | |||
4 | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Ser 42 | - | expression tag |
Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15099.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 590.7 | |
All* | Total formula weight | 15690.1 |