6TZ6
Crystal Structure of Candida Albicans Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Serine/threonine-protein phosphatase | polymer | 411 | 47252.4 | 2 | UniProt (C4YFI3) | Candida albicans (strain WO-1) (Yeast) | |
| 2 | B, E (B, E) | Calcineurin subunit B | polymer | 173 | 19453.9 | 2 | UniProt (C4YS24) | Candida albicans (strain WO-1) (Yeast) | |
| 3 | C, F (C, F) | FK506-binding protein 1 | polymer | 127 | 13563.3 | 2 | UniProt (P28870) Pfam (PF00254) | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | FKBP,Peptidyl-prolyl cis-trans isomerase,PPIase,Rapamycin-binding protein |
| 4 | G, O, R (A, D) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) PubChem (1061) | |||
| 5 | H, P (A, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I, Q (A, D) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) PubChem (29936) | |||
| 7 | J, S (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | K, L, M, T, U... (B, E) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) PubChem (271) | |||
| 9 | N, X (C, F) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 2 | Chemie (FK5) PubChem (23377000) PubChem (54611630) PubChem (57206900) PubChem (59042420) PubChem (59111253) PubChem (59112447) PubChem (59118415) PubChem (59746606) PubChem (59917266) PubChem (59918741) PubChem (60086106) PubChem (66509027) PubChem (66672804) PubChem (71296869) PubChem (71316759) PubChem (71668407) PubChem (73265325) PubChem (89068341) PubChem (124511204) PubChem (125039860) PubChem (125039861) PubChem (125136699) PubChem (125136700) PubChem (125182986) PubChem (126687738) PubChem (129606865) PubChem (131668141) PubChem (137546410) PubChem (137546581) PubChem (138574025) PubChem (139032034) PubChem (140652196) PubChem (143265740) PubChem (144640477) PubChem (146323807) PubChem (156417380) PubChem (156528350) PubChem (160433487) PubChem (163027398) PubChem (163027401) PubChem (163027402) PubChem (167413568) PubChem (170997009) PubChem (171122179) PubChem (171137683) PubChem (171156312) PubChem (171322980) PubChem (171329370) PubChem (172634670) PubChem (175667550) PubChem (177746942) PubChem (23308325) PubChem (23581796) PubChem (24978521) PubChem (44294761) PubChem (44314852) PubChem (44575549) PubChem (46783859) PubChem (46781577) PubChem (49874294) PubChem (57417278) PubChem (57892354) PubChem (57910335) PubChem (58584114) PubChem (59032416) PubChem (58946030) PubChem (59141120) PubChem (59049316) PubChem (59974193) PubChem (59993548) PubChem (60035606) PubChem (66709866) PubChem (67340654) PubChem (67626881) PubChem (68219140) PubChem (68712665) PubChem (69247758) PubChem (176478128) PubChem (176856280) PubChem (177675132) PubChem (5372) PubChem (64779) PubChem (445643) PubChem (77906388) PubChem (89249909) PubChem (89545901) PubChem (89960652) PubChem (145857191) PubChem (117646237) PubChem (6426916) PubChem (6436007) PubChem (6473866) PubChem (123552884) PubChem (9832283) PubChem (9853905) PubChem (125039862) PubChem (9918805) PubChem (125136698) PubChem (125136697) PubChem (9963169) PubChem (129009965) PubChem (129010422) PubChem (130330191) PubChem (131676819) PubChem (133562888) PubChem (133688365) PubChem (11556866) PubChem (134694629) PubChem (12134936) PubChem (13006299) PubChem (137705868) PubChem (138106951) PubChem (138574020) PubChem (140494820) PubChem (13819070) PubChem (140647114) PubChem (13819074) PubChem (13819069) PubChem (140893615) PubChem (149048732) PubChem (160433486) PubChem (162711219) PubChem (163027397) PubChem (163027399) PubChem (163027400) PubChem (166023667) PubChem (168312998) PubChem (170277719) PubChem (171042252) PubChem (171360199) PubChem (172042935) PubChem (173882479) PubChem (403209) PubChem (439492) PubChem (5353987) PubChem (5472317) PubChem (6536850) PubChem (6610362) PubChem (6912836) PubChem (9940643) PubChem (13819073) | |||
| 10 | AA, BA, CA, DA, Y... (C, D, E, F, A...) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, D: 54 - 445 (UniProt: C4YFI3)
C, F: 1 - 124 (UniProt: P28870)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | expression tag |
| Gly 36 | - | expression tag |
| Ser 37 | - | expression tag |
| Ser 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Ser 46 | - | expression tag |
| Gly 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Val 49 | - | expression tag |
| Pro 50 | - | expression tag |
| Arg 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 160539.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2540.1 | |
| All* | Total formula weight | 163079.5 |
