6TZ6
Crystal Structure of Candida Albicans Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Serine/threonine-protein phosphatase | polymer | 411 | 47252.4 | 2 | UniProt (C4YFI3) Pfam (PF00149) | Candida albicans (strain WO-1) (Yeast) | |
| 2 | B, E (B, E) | Calcineurin subunit B | polymer | 173 | 19453.9 | 2 | UniProt (C4YS24) Pfam (PF13499) | Candida albicans (strain WO-1) (Yeast) | |
| 3 | C, F (C, F) | FK506-binding protein 1 | polymer | 127 | 13563.3 | 2 | UniProt (P28870) Pfam (PF00254) | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | FKBP,Peptidyl-prolyl cis-trans isomerase,PPIase,Rapamycin-binding protein |
| 4 | G, O, R (A, D) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 5 | H, P (A, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I, Q (A, D) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 7 | J, S (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | K, L, M, T, U... (B, E) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) | |||
| 9 | N, X (C, F) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 2 | Chemie (FK5) | |||
| 10 | AA, BA, CA, DA, Y... (C, D, E, F, A...) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, D: 54 - 445 (UniProt: C4YFI3)
C, F: 1 - 124 (UniProt: P28870)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | expression tag |
| Gly 36 | - | expression tag |
| Ser 37 | - | expression tag |
| Ser 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Ser 46 | - | expression tag |
| Gly 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Val 49 | - | expression tag |
| Pro 50 | - | expression tag |
| Arg 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 160539.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2540.1 | |
| All* | Total formula weight | 163079.5 |
