6TYS

A potent cross-neutralizing antibody targeting the fusion glycoprotein inhibits Nipah virus and Hendra virus infection

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G (A, B, E)	Fusion glycoprotein F0	polymer	538	59704.8	3	UniProt (Q9IH63) Pfam (PF00523)	Nipah virus	Protein F
2	B, E, H (H, C, F)	5B3 antibody heavy chain	polymer	120	13245.8	3		Mus musculus (Mouse)
3	C, F, I (L, D, G)	5B3 antibody light chain	polymer	107	11517.8	3		Mus musculus (Mouse)
4	J, M, N, Q, R... (I, M, N, Q, R...)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	6	In PDB GlyTouCan (G62182OO)
5	K, O, S (J, O, S)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
6	L, P, T (K, P, T)	alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose	branched		504.4	3	In PDB GlyTouCan (G04118VH)
7	AA, V, W, X, Y... (E, A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

A, B, E: 1 - 494 (UniProt: Q9IH63)

PDB	External Database	Details
Cys 100	Asn 100	conflict
Asp 104	-	insertion
Tyr 104	-	insertion
Lys 104	-	insertion
Asp 104	-	insertion
Asp 104	-	insertion
Asp 104	-	insertion
Asp 104	-	insertion
Lys 104	-	insertion
Cys 119	Ala 119	conflict

A, B, E: 495 - 530 (PDB: 6TYS)

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	253405.1
Branched	Number of molecules	12
	Total formula weight	6305.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	261038.1

*Water molecules are not included.