6TY1

Crystal structure of the haemagglutinin mutant (Gln226Leu, Gly228Ser) from an H10N7 seal influenza virus isolated in Germany in complex with human receptor analogue 6'-SLN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Hemagglutinin	polymer	325	35514.1	6	UniProt (A0A0A7HR51) Pfam (PF00509)	Influenza A virus (A/harbour seal/Germany/1/2014(H10N7))
2	B, D, F, H, J... (B, D, F, H, J...)	Hemagglutinin HA2	polymer	177	20313.4	6	UniProt (A0A0A7HR51) Pfam (PF00509)	Influenza A virus (A/harbour seal/Germany/1/2014(H10N7))
3	M, P (M, P)	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		674.6	2	In PDB BIRD (PRD_900046) GlyTouCan (G73578JC)		6'-sialyl-N-acetyllactosamine
4	N, O (N, O)	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose	branched		471.4	2	In PDB GlyTouCan (G63069TR)
5	Q, R, S, T, V... (D, F, H, I, J...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
6	U, X (I, K)	N-acetyl-alpha-neuraminic acid	non-polymer		309.3	2	Chemie (SIA)
7	AA, Z (I, B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K: 1 - 323 (UniProt: A0A0A7HR51)

PDB	External Database	Details
Asp -1	-	expression tag
Pro 0	-	expression tag
Ser 221	Gly 230	engineered mutation

B, D, F, H, J, L: 1 - 176 (UniProt: A0A0A7HR51)

PDB	External Database	Details
Lys 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	334965.2
Branched	Number of molecules	4
	Total formula weight	2292.0
Non-Polymers*	Number of molecules	9
	Total formula weight	2167.0
All*	Total formula weight	339424.2

*Water molecules are not included.