6TXV
A25T Transthyretin structure in complex with Tolcalpone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transthyretin | polymer | 116 | 12733.2 | 2 | UniProt (P02766) Pfam (PF00576) | Homo sapiens (Human) | ATTR,Prealbumin,TBPA |
| 2 | C, D (A, B) | Tolcapone | non-polymer | 273.2 | 2 | Chemie (TCW) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A, B: 10 - 125 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Thr 25 | Ala 45 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25466.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 546.5 | |
| All* | Total formula weight | 26013.0 |
