6TXE
Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dTMPNPP and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 520 | 60208.8 | 16 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | AC, BD, EA, GB, HC... (J, N, C, G, K...) | FE (III) ION | non-polymer | 55.8 | 16 | Chemie (FE) PubChem (29936) | |||
| 3 | AB, BC, CC, CD, DD... (F, J, N, C, G...) | MAGNESIUM ION | non-polymer | 24.3 | 32 | Chemie (MG) PubChem (888) | |||
| 4 | BB, DC, ED, HA, JB... (F, J, N, C, G...) | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine | non-polymer | 481.2 | 16 | Chemie (1FZ) PubChem (454113) | |||
| 5 | AA, CB, FD, KA, KB... (B, F, N, D, G...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 16 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | AD, CA, DA, EB, FB... (N, B, C, F, G...) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 16 | Chemie (DTP) PubChem (622) PubChem (15993) PubChem (44119995) PubChem (448808) PubChem (46936612) PubChem (57233913) PubChem (91632917) PubChem (92341128) PubChem (92449119) PubChem (92449120) PubChem (89346292) PubChem (129069956) PubChem (171699368) | |||
| 7 | BA, DB, EC, GD, IA... (B, F, J, N, C...) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 963340.9 | |
| Non-Polymers* | Number of molecules | 107 |
| Total formula weight | 26656.7 | |
| All* | Total formula weight | 989997.7 |
