6TXE
Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dTMPNPP and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 520 | 60208.8 | 16 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | AC, BD, EA, GB, HC... (J, N, C, G, K...) | FE (III) ION | non-polymer | 55.8 | 16 | Chemie (FE) | |||
| 3 | AB, BC, CC, CD, DD... (F, J, N, C, G...) | MAGNESIUM ION | non-polymer | 24.3 | 32 | Chemie (MG) | |||
| 4 | BB, DC, ED, HA, JB... (F, J, N, C, G...) | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine | non-polymer | 481.2 | 16 | Chemie (1FZ) | |||
| 5 | AA, CB, FD, KA, KB... (B, F, N, D, G...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 16 | Chemie (GTP) | |||
| 6 | AD, CA, DA, EB, FB... (N, B, C, F, G...) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 16 | Chemie (DTP) | |||
| 7 | BA, DB, EC, GD, IA... (B, F, J, N, C...) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 963340.9 | |
| Non-Polymers* | Number of molecules | 107 |
| Total formula weight | 26656.7 | |
| All* | Total formula weight | 989997.7 |
