Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6TWF

Human CD73 (ecto 5'-nucleotidase) in complex with PSB12604 (an AOPCP derivative, compound 21 in publication) in the closed state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A5'-nucleotidasepolymer53259260.41UniProt (P21589)
Pfam (PF00149)
Pfam (PF02872)
In PDB
Homo sapiens (Human)5'-NT,Ecto-5'-nucleotidase
2AZINC IONnon-polymer65.42Chemie (ZN)
3ACALCIUM IONnon-polymer40.11Chemie (CA)
4A[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-piperazin-4-ium-1-yl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acidnon-polymer510.41Chemie (O05)
5waterwater18.04Chemie (HOH)
Sequence modifications
A: 27 - 549 (UniProt: P21589)
PDBExternal DatabaseDetails
Met 26-initiating methionine
Asp 53Asn 53engineered mutation
Asp 311Asn 311engineered mutation
Asp 333Asn 333engineered mutation
Ala 376Thr 376engineered mutation
Asp 403Asn 403engineered mutation
Leu 550-expression tag
Glu 551-expression tag
His 552-expression tag
His 553-expression tag
His 554-expression tag
His 555-expression tag
His 556-expression tag
His 557-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight59260.4
Non-Polymers*Number of molecules4
Total formula weight681.3
All*Total formula weight59941.7
*Water molecules are not included.

221716

PDB entries from 2024-06-26

PDB statisticsPDBj update infoContact PDBjnumon