6TVG

Human CD73 (ecto 5'-nucleotidase) in complex with AMPCP in the open state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	5'-nucleotidase, ecto (CD73), isoform CRA_a	polymer	546	60464.3	1	UniProt (Q53Z63) Pfam (PF00149) Pfam (PF02872) UniProt (by SIFTS) (P21589)	Homo sapiens (Human)	Ecto-5'-nucleotidase
2	B, C (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D (A)	PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	non-polymer		425.2	1	Chemie (AP2)
4	E (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	F (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	G (A)	water	water		18.0	549	Chemie (HOH)

Sequence modifications

A: 27 - 549 (UniProt: Q53Z63)

PDB	External Database	Details
Met 4	-	initiating methionine
Ala 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Val 12	-	expression tag
Gly 13	-	expression tag
Thr 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag
Asn 17	-	expression tag
Asp 18	-	expression tag
Asp 19	-	expression tag
Asp 20	-	expression tag
Asp 21	-	expression tag
Lys 22	-	expression tag
Ser 23	-	expression tag
Pro 24	-	expression tag
Asp 25	-	expression tag
Pro 26	-	expression tag
Asp 53	Asn 53	conflict
Ser 145	Lys 145	conflict
Ser 147	Lys 147	conflict
Asp 311	Asn 311	conflict
Asp 333	Asn 333	conflict
Asp 403	Asn 403	conflict
Ser 478	Lys 478	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60464.3
Non-Polymers*	Number of molecules	5
	Total formula weight	619.1
All*	Total formula weight	61083.5

*Water molecules are not included.