6TTQ
PKM2 in complex with Compound 10
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Pyruvate kinase PKM | polymer | 548 | 59831.8 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (Human) | Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58 |
2 | A, C | 1-propan-2-yl-3-pyridin-4-yl-urea | non-polymer | 179.2 | 4 | Chemie (NXH) | |||
3 | A, B, C, D | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) | |||
4 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 531 (UniProt: P14618)
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
Gly -15 | - | expression tag |
Ser -14 | - | expression tag |
Ser -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Ser -6 | - | expression tag |
Ser -5 | - | expression tag |
Gly -4 | - | expression tag |
Leu -3 | - | expression tag |
Val -2 | - | expression tag |
Pro -1 | - | expression tag |
Arg 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 239327.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2077.3 | |
All* | Total formula weight | 241404.6 |