6TS7
Coagulation factor XI protease domain in complex with active site inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor XI | polymer | 238 | 26856.5 | 1 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (Human) | FXI,Plasma thromboplastin antecedent,PTA |
| 2 | B (A) | 2-[2-[[3-(1,2,3,4-tetrahydroisoquinolin-7-yl)phenyl]methoxy]phenyl]ethanoic acid | non-polymer | 373.4 | 1 | Chemie (NWE) | |||
| 3 | C (A) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 16 - 245 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ser 123 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26856.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 373.4 | |
| All* | Total formula weight | 27229.9 |
