6TQ1

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-(1-(1,3-dimethoxypropan-2-yl)-5-morpholino-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (AAA, BBB, CCC)	Bromodomain-containing protein 2	polymer	155	18039.9	3	UniProt (P25440) Pfam (PF00439)	Homo sapiens (Human)	O27.1.1,Really interesting new gene 3 protein
2	D, E, K (AAA, CCC)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	F, H, L (AAA, BBB, CCC)	5-(3-methoxyphenyl)-1-methyl-pyridin-2-one	non-polymer		215.2	3	Chemie (NUH)
4	G, I, J (AAA, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	M, N, O (AAA, BBB, CCC)	water	water		18.0	330	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC: 67 - 200 (UniProt: P25440)

PDB	External Database	Details
Met 46	-	initiating methionine
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	54119.8
Non-Polymers*	Number of molecules	9
	Total formula weight	1120.1
All*	Total formula weight	55239.9

*Water molecules are not included.