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6TOD

Crystal structure of the Orexin-1 receptor in complex with EMPA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Orexin receptor type 1polymer33638162.92UniProt (O43613)
Pfam (PF00001)
Homo sapiens (Human)Ox1R,Hypocretin receptor type 1
2C, GA
(A, B)
N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamidenon-polymer454.52Chemie (7MA)
3D, HA, IA
(A, B)
SULFATE IONnon-polymer96.13Chemie (SO4)
4E, F, G, JA, KA
(A, B)
TETRAETHYLENE GLYCOLnon-polymer194.25Chemie (PG4)
5H
(A)
CITRIC ACIDnon-polymer192.11Chemie (CIT)
6AA, AB, BA, BB, CA...
(A, B)
octyl 1-thio-beta-D-glucopyranosidenon-polymer308.447Chemie (SOG)
7EA, KB
(A, B)
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoatenon-polymer749.02Chemie (PGW)
8FA, LB
(A, B)
SODIUM IONnon-polymer23.02Chemie (NA)
9MB, NB
(A, B)
waterwater18.0211Chemie (HOH)
Sequence modifications
A, B: 28 - 380 (UniProt: O43613)
PDBExternal DatabaseDetails
Ala 25-expression tag
Ala 26-expression tag
Ser 27-expression tag
Ala 46Glu 46engineered mutation
Leu 85Ile 85engineered mutation
Ala 95Val 95engineered mutation
Thr 127Ala 127engineered mutation
Leu 162Arg 162engineered mutation
Ala 194Asn 194engineered mutation
Ala 198Leu 198engineered mutation
Ala 211Tyr 211engineered mutation
-Ala 253deletion
-Leu 254deletion
-Val 255deletion
-Arg 256deletion
-Asn 257deletion
-Trp 258deletion
-Lys 259deletion
-Arg 260deletion
-Pro 261deletion
-Ser 262deletion
-Asp 263deletion
-Gln 264deletion
-Leu 265deletion
-Gly 266deletion
-Asp 267deletion
-Leu 268deletion
-Glu 269deletion
-Gln 270deletion
-Gly 271deletion
-Leu 272deletion
-Ser 273deletion
-Gly 274deletion
-Glu 275deletion
-Pro 276deletion
-Gln 277deletion
-Pro 278deletion
-Arg 279deletion
-Ala 280deletion
-Arg 281deletion
-Ala 282deletion
-Phe 283deletion
-Leu 284deletion
Val 304Leu 304engineered mutation
Ala 339Cys 339engineered mutation
Trp 375Cys 375engineered mutation
Trp 376Cys 376engineered mutation
Ala 381-expression tag
Ala 382-expression tag
Ala 383-expression tag
His 384-expression tag
His 385-expression tag
His 386-expression tag
His 387-expression tag
His 388-expression tag
His 389-expression tag
His 390-expression tag
His 391-expression tag
His 392-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight76325.8
Non-Polymers*Number of molecules62
Total formula weight18400.9
All*Total formula weight94726.7
*Water molecules are not included.

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PDB entries from 2024-11-20

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