6TNY

Processive human polymerase delta holoenzyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA polymerase delta catalytic subunit	polymer	1107	123785.9	1	UniProt (P28340) Pfam (PF03104) Pfam (PF00136) Pfam (PF14260) In PDB	Homo sapiens (Human)	DNA polymerase subunit delta p125
2	B	DNA polymerase delta subunit 2	polymer	469	51338.2	1	UniProt (P49005) Pfam (PF18018) Pfam (PF04042) In PDB	Homo sapiens (Human)	DNA polymerase delta subunit p50
3	C	DNA polymerase delta subunit 3	polymer	474	52528.5	1	UniProt (Q15054) Pfam (PF09507) In PDB	Homo sapiens (Human)	DNA polymerase delta subunit C,DNA polymerase delta subunit p66,DNA polymerase delta subunit p68
4	D	DNA polymerase delta subunit 4	polymer	137	16274.3	1	UniProt (Q9HCU8) Pfam (PF04081) In PDB	Homo sapiens (Human)	DNA polymerase delta subunit p12
5	E, F, G	Proliferating cell nuclear antigen	polymer	264	29088.1	3	UniProt (P12004) Pfam (PF00705) Pfam (PF02747) In PDB	Homo sapiens (Human)	PCNA,Cyclin
6	P	DNA primer	polymer	25	7666.0	1		synthetic construct
7	T	DNA template	polymer	38	11677.5	1		synthetic construct
8	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
9	A	IRON/SULFUR CLUSTER	non-polymer		351.6	1	Chemie (SF4)
10	A	THYMIDINE-5'-TRIPHOSPHATE	non-polymer		482.2	1	Chemie (TTP)

Sequence modifications

C: 2 - 466 (UniProt: Q15054)

PDB	External Database	Details
Met -7	-	initiating methionine
Trp -6	-	expression tag
Ser -5	-	expression tag
His -4	-	expression tag
Pro -3	-	expression tag
Gln -2	-	expression tag
Phe -1	-	expression tag
Glu 0	-	expression tag
Lys 1	-	expression tag

D: 2 - 107 (UniProt: Q9HCU8)

PDB	External Database	Details
Met -29	-	initiating methionine
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
Ser -22	-	expression tag
Arg -21	-	expression tag
Ala -20	-	expression tag
Trp -19	-	expression tag
Arg -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Gly -13	-	expression tag
Gly -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag

E, F, G: 1 - 261 (UniProt: P12004)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	350534.6
Non-Polymers*	Number of molecules	3
	Total formula weight	899.2
All*	Total formula weight	351433.8

*Water molecules are not included.