6TIA
IRAK4 IN COMPLEX WITH inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Interleukin-1 receptor-associated kinase 4 | polymer | 308 | 34635.0 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | A, B | 4-(1-methylcyclopropyl)oxy-~{N}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | non-polymer | 459.5 | 10 | Chemie (ND2) | |||
| 3 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69270.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 4595.5 | |
| All* | Total formula weight | 73865.5 |
