6THW
IRAK4 in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Interleukin-1 receptor-associated kinase 4 | polymer | 308 | 34475.1 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
2 | A, B | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{N}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | non-polymer | 489.5 | 2 | Chemie (NBK) | |||
3 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 460 (UniProt: Q9NWZ3)
PDB | External Database | Details |
---|---|---|
Gly 153 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 68950.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 979.1 | |
All* | Total formula weight | 69929.2 |