6TFP
BTK in complex with LOU064, a potent and highly selective covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Tyrosine-protein kinase BTK | polymer | 276 | 32011.7 | 5 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | F, I (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 3 | G, H, J, K, L (A, B, C, D, E) | ~{N}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | non-polymer | 509.5 | 5 | Chemie (N6Z) | |||
| 4 | M, N, O, P, Q (A, B, C, D, E) | water | water | 18.0 | 653 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 385 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 160058.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2593.7 | |
| All* | Total formula weight | 162652.3 |
