6TDQ
Crystal structure of the disulfide engineered HLA-A0201 molecule in complex with one GM dipeptide in the A pocket and one GM dipeptide in the F pocket.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | MHC class I antigen | polymer | 276 | 31925.4 | 2 | UniProt (F6IQS1) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 2 | B, D | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 3 | A, B, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 4 | A, C | GLYCINE | non-polymer | 75.1 | 4 | Chemie (GLY) | |||
| 5 | A, C | METHIONINE | non-polymer | 149.2 | 4 | Chemie (MET) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 1173 | Chemie (HOH) |
Sequence modifications
A, C: 0 - 275 (UniProt: F6IQS1)
B, D: 2 - 100 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Cys 84 | Tyr 108 | conflict |
| Cys 139 | Ala 163 | conflict |
| Val 245 | Ala 269 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 87609.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1491.2 | |
| All* | Total formula weight | 89100.6 |
