6TDE

Tubulin-inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Tubulin alpha chain	polymer	451	50204.4	2	Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (D0VWZ0) In PDB	Ovis aries (Sheep)
2	B, D	Tubulin beta chain	polymer	445	49999.9	2	Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (D0VWY9) In PDB	Ovis aries (Sheep)
3	E	Stathmin-4	polymer	143	16746.0	1	UniProt (P63043) Pfam (PF00836) In PDB	Rattus norvegicus (Norway rat)	Stathmin-like protein B3,RB3
4	A, B, C, D	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
5	A, C	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	A, C	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	B, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
8	B, D	~{N}-[(10~{S})-3,4,5-trimethoxy-16-methylidene-14-oxatetracyclo[9.7.0.0^{2,7}.0^{13,17}]octadeca-1(18),2,4,6,11,13(17)-hexaen-10-yl]ethanamide	non-polymer		395.4	2	Chemie (N3Z)
9		water	water		18.0	173	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Ace 3	-	acetylation
Ala 4	-	expression tag
Ala 14	Cys 58	engineered mutation
Trp 20	Phe 64	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	217154.6
Non-Polymers*	Number of molecules	17
	Total formula weight	3636.8
All*	Total formula weight	220791.5

*Water molecules are not included.