6TDE
Tubulin-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha chain | polymer | 451 | 50204.4 | 2 | UniProt (by SIFTS) (D0VWZ0) | Ovis aries (Sheep) | |
| 2 | B, D (B, D) | Tubulin beta chain | polymer | 445 | 49999.9 | 2 | UniProt (by SIFTS) (D0VWY9) | Ovis aries (Sheep) | |
| 3 | E (E) | Stathmin-4 | polymer | 143 | 16746.0 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F, I, J, M, N... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 5 | G, P (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 6 | H, Q (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | K, U (B, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 8 | L, V (B, D) | ~{N}-[(10~{S})-3,4,5-trimethoxy-16-methylidene-14-oxatetracyclo[9.7.0.0^{2,7}.0^{13,17}]octadeca-1(18),2,4,6,11,13(17)-hexaen-10-yl]ethanamide | non-polymer | 395.4 | 2 | Chemie (N3Z) | |||
| 9 | AA, W, X, Y, Z (E, A, B, C, D) | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
| PDB | External Database | Details |
|---|---|---|
| Ace 3 | - | acetylation |
| Ala 4 | - | expression tag |
| Ala 14 | Cys 58 | engineered mutation |
| Trp 20 | Phe 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 217154.6 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3636.8 | |
| All* | Total formula weight | 220791.5 |
