6TB2

Structure of human haptoglobin-hemoglobin bound to S. aureus IsdH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hemoglobin subunit alpha	polymer	141	15150.4	1	UniProt (P69905) Pfam (PF00042) In PDB	Homo sapiens (Human)	Alpha-globin,Hemoglobin alpha chain
2	B	Hemoglobin subunit beta	polymer	146	15890.2	1	UniProt (P68871) Pfam (PF00042) In PDB	Homo sapiens (Human)	Beta-globin,Hemoglobin beta chain
3	C	Haptoglobin	polymer	267	29787.9	1	UniProt (P00738) Pfam (PF00089) In PDB	Homo sapiens (Human)	Zonulin
4	D, E	Cell wall surface anchor family protein	polymer	354	40971.7	2	UniProt (A0A0E8IWL6) Pfam (PF05031) Pfam (PF20861) UniProt (by SIFTS) (Q2FXJ2) In PDB	Staphylococcus aureus	Haptoglobin-binding heme uptake protein HarA,Heme transporter HarA
5	A, B	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)

Sequence modifications

C: 148 - 406 (UniProt: P00738)

PDB	External Database	Details
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
Ser 184	Asn 184	conflict
Ser 207	Asn 207	conflict
Ser 211	Asn 211	conflict
Ser 241	Asn 241	conflict

D, E: 321 - 655 (UniProt: A0A0E8IWL6)

PDB	External Database	Details
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
Ser 308	-	expression tag
Ser 309	-	expression tag
Gly 310	-	expression tag
Leu 311	-	expression tag
Val 312	-	expression tag
Pro 313	-	expression tag
Arg 314	-	expression tag
Gly 315	-	expression tag
Ser 316	-	expression tag
His 317	-	expression tag
Met 318	-	expression tag
Leu 319	-	expression tag
Glu 320	-	expression tag
Ala 642	Tyr 642	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	142771.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1233.0
All*	Total formula weight	144004.9

*Water molecules are not included.