6TA3

Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Tubulin beta chain	polymer	429	48113.1	1	UniProt (P02554) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Beta-tubulin
2	B (A)	Tubulin alpha-1B chain	polymer	438	48780.1	1	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
3	C (K)	Kinesin-like protein KIF11	polymer	391	43727.5	1	UniProt (P52732) Pfam (PF00225)	Homo sapiens (Human)	Kinesin-like protein 1,Kinesin-like spindle protein HKSP,Kinesin-related motor protein Eg5,Thyroid receptor-interacting protein 5,TRIP-5
4	D, F (B, A)	PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER	non-polymer		521.2	2	Chemie (G2P)
5	E, G (B, A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	H (K)	6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one	non-polymer		291.3	1	Chemie (MZK)

Sequence modifications

K: 1 - 369 (UniProt: P52732)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	140620.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1382.3
All*	Total formula weight	142003.0

*Water molecules are not included.