6TA0

Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	503	57000.5	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (Human)	Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C, E (A)	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	2	Chemie (PRP)
3	D, G (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	F, H (A, B)	NICOTINIC ACID	non-polymer		123.1	2	Chemie (NIO)
5	I, J (A, B)	water	water		18.0	840	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Met -11	-	initiating methionine
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114000.9
Non-Polymers*	Number of molecules	6
	Total formula weight	1210.5
All*	Total formula weight	115211.5

*Water molecules are not included.