6T4T
ROR(gamma)t ligand binding domain in complex with 20-alpha-hydroxycholesterol and allosteric ligand FM26
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 241 | 28184.7 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | 4-[(~{E})-[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methylideneamino]benzoic acid | non-polymer | 459.8 | 1 | Chemie (L3E) | |||
| 4 | E (A) | (3alpha,8alpha)-cholest-5-ene-3,20-diol | non-polymer | 402.7 | 1 | Chemie (HCD) | |||
| 5 | F (A) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A: 267 - 507 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| His 455 | Cys 455 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28184.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1046.6 | |
| All* | Total formula weight | 29231.3 |
