6T2W
Crystal structure of the CSF1R kinase domain with a dihydropurinone inhibitor (compound 4)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor | polymer | 332 | 37327.8 | 1 | UniProt (P07333) Pfam (PF07714) | Homo sapiens (Human) | CSF-1 receptor,M-CSF-R,Proto-oncogene c-Fms |
| 2 | B (A) | 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one | non-polymer | 383.4 | 1 | Chemie (M9T) | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A: 542 - 919 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| - | Gly 696 | deletion |
| - | Val 697 | deletion |
| - | Asp 698 | deletion |
| - | Tyr 699 | deletion |
| - | Lys 700 | deletion |
| - | Asn 701 | deletion |
| - | Ile 702 | deletion |
| - | His 703 | deletion |
| - | Leu 704 | deletion |
| - | Glu 705 | deletion |
| - | Lys 706 | deletion |
| - | Lys 707 | deletion |
| - | Tyr 708 | deletion |
| - | Val 709 | deletion |
| - | Arg 710 | deletion |
| - | Arg 711 | deletion |
| - | Asp 712 | deletion |
| - | Ser 713 | deletion |
| - | Gly 714 | deletion |
| - | Phe 715 | deletion |
| - | Ser 716 | deletion |
| - | Ser 717 | deletion |
| - | Gln 718 | deletion |
| - | Gly 719 | deletion |
| - | Val 720 | deletion |
| - | Asp 721 | deletion |
| - | Thr 722 | deletion |
| - | Tyr 723 | deletion |
| - | Val 724 | deletion |
| - | Glu 725 | deletion |
| - | Met 726 | deletion |
| - | Arg 727 | deletion |
| - | Pro 728 | deletion |
| - | Val 729 | deletion |
| - | Ser 730 | deletion |
| - | Thr 731 | deletion |
| - | Ser 732 | deletion |
| - | Ser 733 | deletion |
| - | Asn 734 | deletion |
| - | Asp 735 | deletion |
| - | Ser 736 | deletion |
| - | Phe 737 | deletion |
| - | Ser 738 | deletion |
| - | Glu 739 | deletion |
| - | Gln 740 | deletion |
| - | Asp 741 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37327.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 767.7 | |
| All* | Total formula weight | 38095.5 |
