6T0J
Crystal structure of CYP124 in complex with SQ109
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methyl-branched lipid omega-hydroxylase | polymer | 435 | 48838.9 | 1 | UniProt (P9WPP3) Pfam (PF00067) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Cholest-4-en-3-one C26-monooxygenase,Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming],Cholesterol C26-monooxygenase,Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming],Cytochrome P450 124,Steroid C26-monooxygenase,Steroid C27-monooxygenase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine | non-polymer | 330.6 | 1 | Chemie (RWZ) | |||
| 4 | D, E, K, M (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | F (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | G, N (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | H, I, J, L (A) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 8 | O (A) | water | water | 18.0 | 748 | Chemie (HOH) |
Sequence modifications
A: 1 - 428 (UniProt: P9WPP3)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48838.9 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1670.3 | |
| All* | Total formula weight | 50509.2 |
