6SZM
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2009
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Activin receptor type I | polymer | 301 | 34537.6 | 2 | UniProt (Q04771) Pfam (PF07714) | Homo sapiens (Human) | |
| 2 | C, D, E, N (A, B) | 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine | non-polymer | 419.5 | 4 | Chemie (M2Z) | |||
| 3 | F, M, O, S, T (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | G, H, I, J, L... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 5 | K (A) | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 6 | P (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | U, V (A, B) | water | water | 18.0 | 694 | Chemie (HOH) |
Sequence modifications
A, B: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69075.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2689.0 | |
| All* | Total formula weight | 71764.3 |
