6SZ8

Crystal structure of YTHDC1 with fragment 6 (DHU_DC1_034)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	YTH domain-containing protein 1	polymer	183	20967.2	2	UniProt (Q96MU7) Pfam (PF04146) UniProt (by SIFTS) (A0A2K6KCS5)	Homo sapiens (Human)	Splicing factor YT521,YT521-B
2	C, D, F, G, H (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	E (B)	6-pyrrolidin-1-yl-5~{H}-pyrimidine-2,4-dione	non-polymer		181.2	1	Chemie (M1Z)
4	I, J (A, B)	water	water		18.0	391	Chemie (HOH)

Sequence modifications

A, B: 345 - 509 (UniProt: Q96MU7)

PDB	External Database	Details
Met 327	-	initiating methionine
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
Ser 334	-	expression tag
Ser 335	-	expression tag
Gly 336	-	expression tag
Arg 337	-	expression tag
Glu 338	-	expression tag
Asn 339	-	expression tag
Leu 340	-	expression tag
Tyr 341	-	expression tag
Phe 342	-	expression tag
Gln 343	-	expression tag
Gly 344	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	41934.3
Non-Polymers*	Number of molecules	6
	Total formula weight	661.5
All*	Total formula weight	42595.8

*Water molecules are not included.