6SXX
Crystal structure of the bromodomain of human CREBBP in complex with ACA007
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CREBBP | polymer | 119 | 14223.3 | 2 | UniProt (Q92793) Pfam (PF00439) | Homo sapiens (Human) | |
| 2 | C, E, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 3 | D, F (A, B) | (3~{R})-1-ethanoylpyrrolidine-3-carboxylic acid | non-polymer | 157.2 | 2 | Chemie (LXQ) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B: 1081 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ser 1079 | - | expression tag |
| Met 1080 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28446.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 500.5 | |
| All* | Total formula weight | 28947.2 |
