6SUZ
Human prion protein (PrP) fragment 119-231 (G127V V129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Major prion protein | polymer | 99 | 11887.2 | 1 | UniProt (P04156) Pfam (PF00377) | Homo sapiens (Human) | PrP,ASCR,PrP27-30,PrP33-35C |
| 2 | B (H) | ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN | polymer | 215 | 23045.6 | 1 | Mus musculus (House mouse) | ||
| 3 | C (L) | ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN | polymer | 211 | 23154.6 | 1 | Mus musculus (House mouse) | ||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F, G (A, H, L) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A: 125 - 223 (UniProt: P04156)
| PDB | External Database | Details |
|---|---|---|
| Val 127 | Gly 127 | engineered mutation |
| Val 129 | Met 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58087.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 58183.5 |
