6SUO
ERa_L536S (L536S/C381S/C471S,C530S) in complex with a tricyclic indole (compound 6)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 252 | 28655.5 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B | (~{E})-3-[3,5-bis(fluoranyl)-4-[(1~{R},3~{R})-2-(2-fluoranyl-2-methyl-propyl)-1,3-dimethyl-4,9-dihydro-3~{H}-pyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid | non-polymer | 456.5 | 2 | Chemie (LVH) | |||
| 3 | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A, B: 307 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 303 | - | expression tag |
| Ser 304 | - | expression tag |
| His 305 | - | expression tag |
| Met 306 | - | expression tag |
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57311.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 913.0 | |
| All* | Total formula weight | 58224.0 |
