6SSZ
Structure of the Plasmodium falciparum falcipain 2 protease in complex with an (E)-chalcone inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cysteine proteinase falcipain 2a | polymer | 242 | 27179.7 | 2 | UniProt (Q9N6S8) Pfam (PF00112) UniProt (by SIFTS) (Q8I6U4) In PDB | Plasmodium falciparum | Falcipain 2 |
| 2 | A, B | (~{E})-3-(1,3-benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one | non-polymer | 297.3 | 2 | Chemie (JV1) |
Sequence modifications
A, B: -16 - 223 (UniProt: Q9N6S8)
| PDB | External Database | Details |
|---|---|---|
| Gly -18 | - | expression tag |
| Pro -17 | - | expression tag |
| Ala 25 | Cys 285 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54359.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 594.5 | |
| All* | Total formula weight | 54953.8 |
