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6SQO

Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, DE3 ubiquitin-protein ligase Mdm2polymer626920.52UniProt (Q00987)
Pfam (PF13920)
In PDB
Homo sapiens (Human)Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2
2B, EUbiquitin-conjugating enzyme E2 D2polymer14616720.22UniProt (P62837)
Pfam (PF00179)
In PDB
Homo sapiens (Human)(E3-independent) E2 ubiquitin-conjugating enzyme D2,E2 ubiquitin-conjugating enzyme D2,Ubiquitin carrier protein D2,Ubiquitin-conjugating enzyme E2(17)KB 2,Ubiquitin-conjugating enzyme E2-17 kDa 2,Ubiquitin-protein ligase D2,p53-regulated ubiquitin-conjugating enzyme 1
3C, FUbiquitin-40S ribosomal protein S27apolymer778663.92UniProt (J3QTR3)
Pfam (PF00240)
UniProt (by SIFTS) (P62979)
In PDB
Homo sapiens (Human)
4A, DZINC IONnon-polymer65.44Chemie (ZN)
5A, B, D, ECHLORIDE IONnon-polymer35.54Chemie (CL)
6B, ENITRATE IONnon-polymer62.02Chemie (NO3)
7waterwater18.0546Chemie (HOH)
Sequence modifications
B, E: 2 - 147 (UniProt: P62837)
PDBExternal DatabaseDetails
Arg 22Ser 22engineered mutation
Lys 85Cys 85engineered mutation
C, F: 1 - 76 (UniProt: J3QTR3)
PDBExternal DatabaseDetails
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight64609.2
Non-Polymers*Number of molecules10
Total formula weight527.5
All*Total formula weight65136.7
*Water molecules are not included.

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PDB entries from 2024-06-12

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