6SQ3
Crystal structure of mouse PRMT6 in complex with inhibitor U1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein arginine N-methyltransferase 6 | polymer | 386 | 42821.3 | 2 | UniProt (Q6NZB1) Pfam (PF13649) Pfam (PF22528) | Mus musculus (House mouse) | Histone-arginine N-methyltransferase PRMT6 |
| 2 | C, D (A, B) | [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium | non-polymer | 323.3 | 2 | Chemie (6RE) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 378 (UniProt: Q6NZB1)
| PDB | External Database | Details |
|---|---|---|
| Leu 315 | Phe 315 | engineered mutation |
| Gly 379 | - | expression tag |
| Ser 380 | - | expression tag |
| Glu 381 | - | expression tag |
| Asn 382 | - | expression tag |
| Leu 383 | - | expression tag |
| Tyr 384 | - | expression tag |
| Phe 385 | - | expression tag |
| Gln 386 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85642.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 646.7 | |
| All* | Total formula weight | 86289.3 |
