6SLO

Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Thioredoxin,Poly(U)-binding-splicing factor PUF60	polymer	222	24671.9	4	UniProt (A0A064CXU8) UniProt (Q9UHX1) In PDB	Citrobacter freundii MGH 56	60 kDa poly(U)-binding-splicing factor,FUSE-binding protein-interacting repressor,FBP-interacting repressor,Ro-binding protein 1,RoBP1,Siah-binding protein 1,Siah-BP1
2	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	C, D	2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol	non-polymer		464.0	2	Chemie (LJT)
4		water	water		18.0	670	Chemie (HOH)

Sequence modifications

A, B, C, D: 344 - 452 (UniProt: A0A064CXU8)

PDB	External Database	Details
Met 335	-	initiating methionine
Lys 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
Pro 343	-	expression tag
Gly 453	-	linker
Ser 454	-	linker
Ala 455	-	linker
Met 456	-	linker

A, B, C, D: 457 - 556 (UniProt: Q9UHX1)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	98687.7
Non-Polymers*	Number of molecules	4
	Total formula weight	976.7
All*	Total formula weight	99664.4

*Water molecules are not included.