6SLG

HUMAN ERK2 WITH ERK1/2 INHIBITOR, AZD0364.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 1	polymer	381	43909.3	1	UniProt (P28482) Pfam (PF00069)	Homo sapiens (Human)	MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
2	B (B)	ERK-tide	polymer	5	491.6	1		Homo sapiens
3	C (A)	(6~{R})-7-[[3,4-bis(fluoranyl)phenyl]methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one	non-polymer		494.5	1	Chemie (LHZ)
4	D, E (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	F, G, H, I (A)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
6	J (A)	water	water		18.0	199	Chemie (HOH)

Sequence modifications

A: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Met -18	-	initiating methionine
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Gly -11	-	expression tag
Gly -10	-	expression tag
Gly -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Leu 46	Val 46	conflict
Leu 361	-	expression tag
Glu 362	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44400.9
Non-Polymers*	Number of molecules	7
	Total formula weight	934.9
All*	Total formula weight	45335.8

*Water molecules are not included.