6SKD
Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3397892A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Kallikrein-6 | polymer | 223 | 24467.7 | 2 | UniProt (Q92876) Pfam (PF00089) In PDB | Homo sapiens (Human) | Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme |
| 2 | A, B | UNKNOWN ATOM OR ION | non-polymer | 2 | Chemie (UNX) | ||||
| 3 | A, B | 4-[[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]methylamino]benzenecarboximidamide | non-polymer | 295.1 | 2 | Chemie (LH2) | |||
| 4 | B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 245 (UniProt: Q92876)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | Arg 78 | engineered mutation |
| Gln 76 | Arg 80 | engineered mutation |
| Gln 132 | Asn 134 | engineered mutation |
| Tyr 218 | Ile 216 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48935.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 774.5 | |
| All* | Total formula weight | 49709.9 |
