6SJV

Structure of HPV18 E6 oncoprotein in complex with mutant E6AP LxxLL motif

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Maltodextrin-binding protein,Protein E6,Ubiquitin-protein ligase E3A	polymer	543	60651.8	1	UniProt (A0A376KDN7) UniProt (P06463) UniProt (Q05086) Pfam (PF00518) In PDB	Escherichia coli	E6AP ubiquitin-protein ligase,HECT-type ubiquitin transferase E3A,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,Renal carcinoma antigen NY-REN-54
2	B	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4		water	water		18.0	121	Chemie (HOH)

Sequence modifications

A: 2 - 367 (UniProt: A0A376KDN7)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 83	Asp 108	conflict
Ala 84	Lys 109	engineered mutation
Ala 240	Lys 265	engineered mutation
Ala 363	Lys 388	engineered mutation
Ala 364	Asp 389	engineered mutation
Asn 368	-	linker
Ala 369	-	linker
Ala 370	-	linker
Ala 371	-	linker

A: 1001 - 2374 (UniProt: P06463)

PDB	External Database	Details
Arg 1049	Phe 49	engineered mutation
Gly 2375	-	linker
Ser 2376	-	linker
Ala 2377	-	linker
Ala 2378	-	linker
Ala 2379	-	linker

A: 2380 - 2394 (UniProt: Q05086)

PDB	External Database	Details
Phe 2386	Leu 409	engineered mutation
Arg 2393	Glu 416	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60651.8
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	61124.9

*Water molecules are not included.