6SEF

Class2C : CENP-A nucleosome in complex with CENP-C central region

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3-like centromeric protein A	polymer	140	16023.6	2	UniProt (P49450) Pfam (PF00125) In PDB	Homo sapiens (Human)	Centromere autoantigen A,Centromere protein A,CENP-A
2	B, F	Histone H4	polymer	103	11394.4	2	UniProt (P62805) Pfam (PF15511) In PDB	Homo sapiens (Human)
3	C, G	Histone H2A type 2-A	polymer	130	14125.5	2	UniProt (Q6FI13) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (Human)	Histone H2A.2,Histone H2A/o
4	D, H	Histone H2B type 1-C/E/F/G/I	polymer	126	13937.2	2	UniProt (P62807) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H2B.1 A,Histone H2B.a,H2B/a,Histone H2B.g,H2B/g,Histone H2B.h,H2B/h,Histone H2B.k,H2B/k,Histone H2B.l,H2B/l
5	I	DNA (145-MER)	polymer	145	44520.4	1		synthetic construct
6	J	DNA (145-MER)	polymer	145	44991.7	1		synthetic construct
7	V	Centromere protein C	polymer	124	14204.8	1	UniProt (Q03188) Pfam (PF15620) In PDB	Homo sapiens (Human)	CENP-C,Centromere autoantigen C,Centromere protein C 1,CENP-C 1,Interphase centromere complex protein 7

Sequence modifications

V: 426 - 537 (UniProt: Q03188)

PDB	External Database	Details
Gly 414	-	expression tag
Pro 415	-	expression tag
Leu 416	-	expression tag
Gly 417	-	expression tag
Ser 418	-	expression tag
Pro 419	-	expression tag
Glu 420	-	expression tag
Phe 421	-	expression tag
Gly 422	-	expression tag
Arg 423	-	expression tag
Ala 424	-	expression tag
Thr 425	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	214678.4
All*	Total formula weight	214678.4

*Water molecules are not included.