6S9Q
Fragment AZ-004 binding at a primary and secondary site in a p53pT387/14-3-3 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 253 | 28210.5 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (P) | Cellular tumor antigen p53 | polymer | 12 | 1449.5 | 1 | UniProt (P04637) | Homo sapiens | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 3 | C, D, E (A) | 4-methyl-5-phenyl-thiophene-2-carboximidamide | non-polymer | 216.3 | 3 | Chemie (L1T) | |||
| 4 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | G, H (A, P) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: 1 - 248 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29660.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 689.0 | |
| All* | Total formula weight | 30349.0 |
