6S9C
EGFR-KINASE IN COMPLEX WITH COMPOUND 5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 329 | 37422.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | ~{N}-[1-(2-methyl-2-oxidanyl-propyl)benzimidazol-2-yl]-2-phenyl-pyridine-4-carboxamide | non-polymer | 386.4 | 1 | Chemie (L1K) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Ser 694 | - | expression tag |
Met 695 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 858 | Leu 858 | engineered mutation |
Ala 865 | Glu 865 | engineered mutation |
Ala 866 | Glu 866 | engineered mutation |
Ala 867 | Lys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37422.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 464.6 | |
All* | Total formula weight | 37886.9 |