6S8D

Structure of ZEBOV GP in complex with 1T0227 antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L, O, U	Light chain	polymer	218	23138.5	3		Homo sapiens
2	H, P, Y	Heavy chain	polymer	231	24747.7	3		Homo sapiens
3	A, C, E	Envelope glycoprotein	polymer	323	35707.0	3	UniProt (A0A0U3BWW0) Pfam (PF01611) UniProt (by SIFTS) (Q05320) In PDB	Ebola virus
4	B, D, F	Envelope glycoprotein	polymer	168	18989.4	3	UniProt (A0A0U3BWW0) Pfam (PF22307) UniProt (by SIFTS) (Q05320) In PDB	Ebola virus
5	G, I, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)

Sequence modifications

A, C, E: 32 - 334 (UniProt: A0A0U3BWW0)

PDB	External Database	Details
Glu 28	-	expression tag
Thr 29	-	expression tag
Gly 30	-	expression tag
Arg 31	-	expression tag
Ala 42	Thr 42	conflict
Val 310	Ala 310	conflict
Thr 313	Asn 313	conflict
His 314	Arg 314	conflict
His 315	Ala 315	conflict
Gln 316	Lys 316	conflict
Asp 317	Asn 317	conflict
Thr 318	Ile 318	conflict
Gly 319	Ser 319	conflict
Glu 320	Gly 320	conflict
Glu 321	Gln 321	conflict
Ala 323	Pro 323	conflict
Ser 324	Ala 324	conflict
Ser 325	Arg 325	conflict
Gly 326	Thr 326	conflict
Lys 327	Ser 327	conflict
Leu 328	Ser 328	conflict
Gly 329	Asp 329	conflict
Leu 330	Pro 330	conflict
Ile 331	Gly 331	conflict
Ile 335	-	expression tag
Ala 336	-	expression tag
Gly 337	-	expression tag
Val 338	-	expression tag
Ala 339	-	expression tag
Gly 340	-	expression tag
Leu 341	-	expression tag
Ile 342	-	expression tag
Thr 343	-	expression tag
Gly 344	-	expression tag
Gly 345	-	expression tag
Arg 346	-	expression tag
Arg 347	-	expression tag
Thr 348	-	expression tag
Arg 349	-	expression tag
Arg 350	-	expression tag

B, D, F: 502 - 632 (UniProt: A0A0U3BWW0)

PDB	External Database	Details
Gly 633	-	expression tag
Ser 634	-	expression tag
Gly 635	-	expression tag
Tyr 636	-	expression tag
Ile 637	-	expression tag
Pro 638	-	expression tag
Glu 639	-	expression tag
Ala 640	-	expression tag
Pro 641	-	expression tag
Arg 642	-	expression tag
Asp 643	-	expression tag
Gly 644	-	expression tag
Gln 645	-	expression tag
Ala 646	-	expression tag
Tyr 647	-	expression tag
Val 648	-	expression tag
Arg 649	-	expression tag
Lys 650	-	expression tag
Asp 651	-	expression tag
Gly 652	-	expression tag
Glu 653	-	expression tag
Trp 654	-	expression tag
Val 655	-	expression tag
Leu 656	-	expression tag
Leu 657	-	expression tag
Ser 658	-	expression tag
Thr 659	-	expression tag
Phe 660	-	expression tag
Leu 661	-	expression tag
Gly 662	-	expression tag
Thr 663	-	expression tag
His 664	-	expression tag
His 665	-	expression tag
His 666	-	expression tag
His 667	-	expression tag
His 668	-	expression tag
His 669	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	307747.9
Branched	Number of molecules	3
	Total formula weight	1273.2
All*	Total formula weight	309021.1

*Water molecules are not included.