6S89
Crystal Structure of EGFR-T790M/C797S in Complex with Covalent Pyrrolopyrimidine 19g
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 333 | 37715.6 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | ~{N}-[3-[6-[4-(4-methylpiperazin-1-yl)phenyl]-4-propan-2-yloxy-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | non-polymer | 498.6 | 1 | Chemie (L0Q) | |||
3 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 690 | - | expression tag |
Ser 691 | - | expression tag |
His 692 | - | expression tag |
Met 693 | - | expression tag |
Ala 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Ser 797 | Cys 797 | engineered mutation |
Ala 865 | Glu 865 | engineered mutation |
Ala 866 | Glu 866 | engineered mutation |
Ala 867 | Lys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37715.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 693.9 | |
All* | Total formula weight | 38409.5 |