6S7A
Crystal structure of CARM1 in complex with inhibitor AA175
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-arginine methyltransferase CARM1 | polymer | 351 | 40023.5 | 4 | UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) | Homo sapiens (Human) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | E, G, J, L (A, B, C, D) | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyridin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol | non-polymer | 457.5 | 4 | Chemie (KY5) | |||
| 3 | F, H, I, K, M... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 4 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 688 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 135 - 479 (UniProt: Q86X55)
| PDB | External Database | Details |
|---|---|---|
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
| His 483 | - | expression tag |
| His 484 | - | expression tag |
| His 485 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 160093.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2382.7 | |
| All* | Total formula weight | 162476.6 |
