6S79
Crystal structure of CARM1 in complex with inhibitor AA183
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Histone-arginine methyltransferase CARM1 | polymer | 351 | 40023.5 | 4 | UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) In PDB | Homo sapiens (Human) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
2 | A, B, C, D | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid | non-polymer | 501.5 | 4 | Chemie (KXW) | |||
3 | B, C | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 267 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 135 - 479 (UniProt: Q86X55)
PDB | External Database | Details |
---|---|---|
His 480 | - | expression tag |
His 481 | - | expression tag |
His 482 | - | expression tag |
His 483 | - | expression tag |
His 484 | - | expression tag |
His 485 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 160093.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2190.3 | |
All* | Total formula weight | 162284.3 |