6S6K
Crystal Structure of BRD4(1) bound to inhibitor BUX2 (9)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B (A) | ~{N}-[5-(azepan-1-ylsulfonyl)-2-methoxy-phenyl]-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide | non-polymer | 473.6 | 1 | Chemie (KXK) | |||
| 3 | C, D, E, F (A) | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 4 | Chemie (BU3) | |||
| 4 | G (A) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15099.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 834.1 | |
| All* | Total formula weight | 15933.4 |
