6S53
Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, G, I (E, C, K, I) | Ubiquitin-conjugating enzyme E2 N | polymer | 152 | 17125.7 | 4 | UniProt (P61088) Pfam (PF00179) | Homo sapiens (Human) | Bendless-like ubiquitin-conjugating enzyme,E2 ubiquitin-conjugating enzyme N,Ubc13,UbcH13,Ubiquitin carrier protein N,Ubiquitin-protein ligase N |
| 2 | B, D, H, J (F, D, L, J) | Polyubiquitin-C | polymer | 76 | 8576.8 | 4 | UniProt (P0CG48) Pfam (PF00240) | Homo sapiens (Human) | |
| 3 | E, F, K, L (B, A, H, G) | E3 ubiquitin-protein ligase TRIM21 | polymer | 85 | 9510.1 | 4 | UniProt (P19474) Pfam (PF00097) | Homo sapiens (Human) | 52 kDa Ro protein,52 kDa ribonucleoprotein autoantigen Ro/SS-A,RING finger protein 81,RING-type E3 ubiquitin transferase TRIM21,Ro(SS-A),Sjoegren syndrome type A antigen,SS-A,Tripartite motif-containing protein 21 |
| 4 | M, N, O, P, R... (B, A, H, G) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 5 | Q (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 6 | V, W, X, Y (E, C, A, K) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
E, C, K, I: 1 - 152 (UniProt: P61088)
| PDB | External Database | Details |
|---|---|---|
| Lys 87 | Cys 87 | conflict |
| Ala 92 | Lys 92 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 140850.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 641.4 | |
| All* | Total formula weight | 141491.9 |
