6S4F
Structure of human MTHFD2 in complex with TH9619
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | polymer | 316 | 34314.7 | 2 | UniProt (P13995) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (Human) | |
| 2 | C, K (A, B) | (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid | non-polymer | 451.4 | 2 | Chemie (KUN) | |||
| 3 | D, E, F, G, H... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 4 | I (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | J, O (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 350 (UniProt: P13995)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68629.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2273.9 | |
| All* | Total formula weight | 70903.4 |
