6S4E
Structure of human MTHFD2 in complex with TH7299
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | polymer | 316 | 34314.7 | 1 | UniProt (P13995) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (Human) | |
| 2 | B (A) | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid | non-polymer | 433.4 | 1 | Chemie (9L9) | |||
| 3 | C, D, E, F (A) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 4 | G (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 5 | H (A) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 36 - 350 (UniProt: P13995)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34314.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1476.7 | |
| All* | Total formula weight | 35791.4 |
