6S4A
Structure of human MTHFD2 in complex with TH9028
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | polymer | 316 | 34314.7 | 2 | UniProt (P13995) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (Human) | |
| 2 | C, K (A, B) | (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid | non-polymer | 458.4 | 2 | Chemie (KUK) | |||
| 3 | D, E, F, L, M... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 4 | G, O (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 5 | H, I, J, P, Q... (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 7 | Chemie (MPD) | |||
| 6 | T, U (A, B) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 350 (UniProt: P13995)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68629.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3640.7 | |
| All* | Total formula weight | 72270.2 |
