6S41
CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nuclear receptor subfamily 1 group I member 2 | polymer | 323 | 36809.4 | 2 | UniProt (O75469) Pfam (PF00104) In PDB | Homo sapiens (Human) | Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR |
2 | A, B | 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide | non-polymer | 447.9 | 2 | Chemie (KUB) | |||
3 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B: 138 - 672 (UniProt: O75469)
PDB | External Database | Details |
---|---|---|
Gly 673 | - | expression tag |
Gly 674 | - | expression tag |
Ser 675 | - | expression tag |
Gly 676 | - | expression tag |
Gly 677 | - | expression tag |
Ser 678 | - | expression tag |
Ser 679 | - | expression tag |
His 680 | - | expression tag |
Ser 681 | - | expression tag |
Ser 682 | - | expression tag |
Leu 683 | - | expression tag |
Thr 684 | - | expression tag |
Glu 685 | - | expression tag |
Arg 686 | - | expression tag |
His 687 | - | expression tag |
Lys 688 | - | expression tag |
Ile 689 | - | expression tag |
Leu 690 | - | expression tag |
His 691 | - | expression tag |
Arg 692 | - | expression tag |
Leu 693 | - | expression tag |
Leu 694 | - | expression tag |
Gln 695 | - | expression tag |
Glu 696 | - | expression tag |
Gly 697 | - | expression tag |
Ser 698 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73618.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 895.8 | |
All* | Total formula weight | 74514.6 |