6S1O
Human polymerase delta holoenzyme Conformer 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase delta catalytic subunit | polymer | 1107 | 123785.9 | 1 | UniProt (P28340) Pfam (PF03104) Pfam (PF00136) Pfam (PF14260) | Homo sapiens (Human) | DNA polymerase subunit delta p125 |
| 2 | B (B) | DNA polymerase delta subunit 2 | polymer | 469 | 51338.2 | 1 | UniProt (P49005) Pfam (PF18018) Pfam (PF04042) | Homo sapiens (Human) | DNA polymerase delta subunit p50 |
| 3 | C (C) | DNA polymerase delta subunit 3 | polymer | 474 | 52528.5 | 1 | UniProt (Q15054) Pfam (PF09507) | Homo sapiens (Human) | DNA polymerase delta subunit C,DNA polymerase delta subunit p66,DNA polymerase delta subunit p68 |
| 4 | D (D) | DNA polymerase delta subunit 4 | polymer | 137 | 16274.3 | 1 | UniProt (Q9HCU8) Pfam (PF04081) | Homo sapiens (Human) | DNA polymerase delta subunit p12 |
| 5 | E, F, G (E, F, G) | Proliferating cell nuclear antigen | polymer | 264 | 29088.1 | 3 | UniProt (P12004) Pfam (PF00705) Pfam (PF02747) | Homo sapiens (Human) | PCNA,Cyclin |
| 6 | H (P) | DNA primer | polymer | 25 | 7666.0 | 1 | synthetic construct | ||
| 7 | I (T) | DNA template | polymer | 38 | 11677.5 | 1 | synthetic construct | ||
| 8 | J (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 9 | K (A) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 10 | L (T) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) |
Sequence modifications
C: 2 - 466 (UniProt: Q15054)
D: 2 - 107 (UniProt: Q9HCU8)
E, F, G: 1 - 261 (UniProt: P12004)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Trp -6 | - | expression tag |
| Ser -5 | - | expression tag |
| His -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Lys 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -29 | - | initiating methionine |
| His -28 | - | expression tag |
| His -27 | - | expression tag |
| His -26 | - | expression tag |
| His -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| Ser -22 | - | expression tag |
| Arg -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Trp -19 | - | expression tag |
| Arg -18 | - | expression tag |
| His -17 | - | expression tag |
| Pro -16 | - | expression tag |
| Gln -15 | - | expression tag |
| Phe -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Gly -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 350534.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 899.2 | |
| All* | Total formula weight | 351433.8 |
